Emergency services were called to a house on fire at Wilshire Courthouse in Endeavor Hills around 6:30 p.m. yesterday.
Firefighters were on the scene within six minutes and found the entire house already engulfed in flames, according to Fire Rescue Victoria.
They searched the house and evacuated a woman in her 70s who was found inside.
She was taken to Dandenong Hospital for observation.
A man was found dead inside the house.
Firefighters brought the fire under control in 29 minutes.
The police are investigating the incident.